ABOUT CBD

At Cheapo Depot. Our goal is to help you understand the basics of CBD and Products. Keeping it simple in most parts and giving you a little more information when needed. Our goal is to make you an informed consumer. So whatever brand you choose, your choice based on facts not hype.

 

So, what is CBD?

In Short: CBD stands for Cannabidiol. The canabidiol compound is found naturally occurring in hemp plants. These compounds have long been associated with certain health benefits. Such as pain, inflammation, anxiety and more. None of these affects have been approved by the FDA. Yet, many people feel the affect in their everyday life.

The Hemp plant contains more than just CBD. CBD is a generic term of a variety of cannabinoids and the plant also contains many beneficial Terpenes. More about Terpenes

Cannabinoids

Key cannabinoids in hemp:

Cannabidiol (BD) - A major phytocannabinoid, accounting for up to 40% of the plant extract. Extensive research has demonstrated CBD to be a powerful antioxidant and has the potential to treat a myriad of ischemic, age-related, inflammatory, and auto-immune disorders.

Delta 9 Tetrahydrocannabinol (THC) – Yes THC is a cannabinoid. The phytocannabinoid that is responsible for the psychoactive effects of medical cannabis.

Cannabichromene (CBC) - May contribute to the overall analgesic, anti-inflammatory andanti-fungal effects of medical cannabis.

Cannabinol (CBN) - A non-psychoactive cannabinoid with analgesic properties that reportedly aids in sleep and appetite regulation.

Cannabidivarin (CBDV) - A homolog of cannabidiol (CBD) that has been reported to have powerful anti-convulsive effects.

Tetrahydrocannabivarin (THCV) - A non-psychoactive precursor and regulator of various key phytocannabinoids.

Cannabigerivarin (CBGV) - The propyl homologue of cannabigerol (CBG), CBGV has been shown to be holding great potential for treating cancer. CBGV was shown to be cytostatic in leukemic cells and caused a simultaneous arrest at all phases of the cell cycle.

Cannabigerol (CBG) - The non-acidic form of cannabigerolic acid, cannagiberol is an adaptogenic molecule and is the “parent molecule” from which several other cannabinoids are made.

 

Why Do Canabanoids Effect the Body?

CBD works because of The Human Endocannabinoid System

After 35 years of research, scientists have only just begun to understand the importance of the Human Endocannabinoid System (HEcS). The discovery of the HEcS is arguably the most important discovery in human physiology in the late Twentieth Century. Research has revealed that the HEcS is responsible for maintaining and controlling the body’s homeostasis, or balanced regulation of every system in the body. It does that through two known receptors called CB1 & CB2.

While the body produces its own endogenous cannabinoids, many scientists suggest that most people are now suffering from “Cannabinoid Deficiency”. Without enough cannabinoids in our diet, the HEcS operates at less than peak efficiency, resulting in a general decline in overall health. Supplementing our diets with full spectrum phytocannabinoids may be an essential component to achieving optimal health.  More on Endocannabinoid System

 

 

 

Extraction:

The compounds, cannabinoids and terpenes are extracted from the hemp plant in several different ways. The 2 most common are Co2 and Ethanol extraction. Both have their benefits and drawbacks. The choice of extraction method is more the choice of economics, scalability and the product the cannabinoid or terpenes is to be used.

Basics about Oils or Tinctures:

In the CBD industry the 2 terms tincture and oil, are used interchangeably in today’s market. In most cases this does not make a difference. The CBD extract is suspended in some form of carrier oil. Coconut oil being one of the favorite oils used. Other oils may be my used include hemp seed, avocado, olive, grape see and palm.

We use Coconut Oil (MCT). This is called fractionated coconut oil. This oil is a very effective carrier for CBD because it contains 90% saturated fat. That may sound like it has the potential to clog your arteries. But it’s not because the saturated fats in coconuts are primarily made up of medium chain triglycerides (MCTs). Fractionated coconut oil is made from regular coconut oil. But in the process, the long chain fatty acids are removed. Medium chain fatty acids work differently on the metabolism. They go directly to the liver, where they can give you an energy boost. Since the fractionated oil has no flavor at all, and no smell, it is considered by many in the industry to be the best carrier oil of all for sublingual use.

Types of Oils and Blends

There terms and hype associated with the CBD oils and product. Here are the basics of Extract Types.

Full Spectrum Whole Plant Extract:

This extraction method leaves the complete plant profile. Including THC. The complex biochemical interaction of the matrix of phytocannabionoids working synergistically in the body is referred to as the “entourage effect.” Cannabidiol is but one of more than 100 known phytocannabinoids that interact with the body’s endocannabinoid system (ECS) to help restore normal balance and physiological homeostasis. TRUE Full Spectrum Phytocannabinoid-Rich (PCR) hemp oil contains a variety of synergistic compounds, which interact with one another to unlock the full power and potential of the plant. TRUE Full Spectrum Hemp Oil Extract contains a complete array of cannabinoids, including at least trace amounts of THC and terpenes. There certainly are specific health benefits that are attributed to the isolated CBD molecule, but the vast majority of cannabis compound clinical research suggests that the synergistic action of key phytocannabinoids and terpenes working together is truly what offers the widest range of potential medicinal benefits of cannabis. This product will contain less than a legal limit of THC.

Simple example: If you want your Vitamin C (CBD) this would be like squeezing a whole orange. Drinking all the vitamins, minerals, terpenes and other beneficial things the whole squeezed orange has to offer. This would be considered a full spectrum of the orange. Same as ort Full Spectrum Whole Plant Extract Oils.

THC Free Broad-Spectrum Oils. For Those concerned with THC We offer this THC version:

Our Broad-Spectrum THC Free Hemp Oil features numerous phytocannabinoids and has zero percent THC. By an additional processing step this oil is broken down into all the individual cannabinoids and terpenes into their individual compounds and solutions, they are then  recombined into a Broad-Spectrum Oil Containing all the components of our Full Plant extract but leaving out the THC. A lot of brands will label this as a THC Free Full Spectrum but because it doesn’t contain the Full Spectrum of the Plant (THC), our opinion is it should not be marketed as a Full Spectrum.

Simple example: If you want your Vitamin C (CBD) this would be like squeezing a whole orange. But you don’t like pulp (THC). You Strain the Orange Juice to remove the pulp. Leaving all the vitamins, minerals, terpenes and other beneficial things the whole squeezed orange has to offer. This would be considered a broad spectrum of the orange. Same as out Broad-Spectrum Oils.

Isolate or Distillate Oils:

These oils use just the CBD of the hemp plant leaving out all the terpenes and other beneficial cannabinoids the plant has to offer.

Simple example: If you want just Vitamin C (CBD). You take a Vitamin C pill.

  

Hemp Also Contains Terpenes

What are Terpenes?

Terpenes are a naturally occurring chemicals that are present in all plants.  These terpenes are an important part of any plant makeup. The smallest effect of terpenes is the scent and taste of any plant is affected by the terpenes. Ever smell fresh cut pine. That smell is from the terpenes. Terpenes have been found to have many other beneficial effects than smell and taste. Everything from relaxation scent to physical benefits are contributed to terpenes.

Hemp plants produce terpenes in the same glands where they produce THC and CBD, yet terpenes have until recently not received  much attention. Growers and medical researchers have in the past focused on CBD, which means the knowledge about terpenes and their function isn’t too widely spread. Only recently has come to light that terpenes play a major role when it comes to the unique effects of CBD and Hemp. There is evidence that Terpines may help in the absorption of the CBD. Also Some Terpens also have there own effect on the body. These findings showing the role of terpenes in producing very distinctive types effects are now elevating the hemp industry, research, and cultivation to all-new promising levels. Terpenes are now becoming the worthwhile focus of the CBD is interested in the effects of terpenes and their synergy with cannabinoids.

Key Terpenes found in Hemp

Myrcene - Myrcene is the most commonly found terpenes in hemp, making-up most aromatic oils in various hemp strains. Myrcene can also be found in some other plants such as hops. Some compare Myrcene’s aroma to that of cloves. It is known to have anti-inflammatory, anti- bacterial and pain-relieving (analgesic) properties. Myrcene has a sedative, calming and relaxing effect.

Limonene - Limonene is the second-most common terpene that we find in hemp. As the name suggests, it has a strong citrus smell. It is known for its anti-fungal and anti-bacterial properties. Research suggests that limonene also works as an anti-carcinogenic and that it may help preventing the growth of tumors. Limonene can effortlessly enter the blood-brain barrier. It is understood to help increase mental focus and attention, as well as benefiting our general well-being. There is anecdotal evidence that it is also beneficial for sexual health. Some products on the market today use limonene to treat depression and anxiety. It is a natural insect repellent, one of the aromatic terpene’s plants use as a natural defense from insects and other predators. Haze strains are a great source of this terpene.

Linalool - Linalool is reminiscent of fresh flowers. It has a floral lavender smell with a hint of spiciness. It induces a sedative and calming effect and is used for the treatment of nervousness and anxiety. It is thought to have analgesic and anti-epileptic properties. Its effectiveness in treating certain types of cancers is also currently being researched. Linalool is the terpene that is partly responsible for the calming and sedative effects of certain cannabis strains.

Caryophyllene - Caryophyllene is a spicy flavor that is often found in herbs and spices such as black pepper. It is known for being a strong local anti-inflammatory and analgesic. Cloves that are known as being a natural remedy for toothaches contain good amounts of this terpene. Caryophyllene is also said to be anti-fungal.

Pinene - The name might give it away; pinene has a scent that reminds of pine and fir trees. Many plants contain pinene; for example, Rosemary and Sage. This terpene is understood to have anti- inflammatory and local antiseptic properties. It is also known as being an expectorant and has a widening effect on the bronchi. Research has shown that pinene can positively affect our memory. Among those cannabis strains with high levels of pinene are the various Skunk strains. Pinene can boost energy and is said to improve concentration.

Terpineol - Terpineol has the scent of lime blossoms as well as the pleasant smell of lilac. It is often used to make perfumes and cosmetics. Terpineol is one of the terpenes with a sedative and relaxing effect. Cannabis strains that have high levels of terpineol are often also containing high amounts of pinene. The pinene can make it difficult to detect the terpineol just by smell.

Limonene - Limonene is known to allow more efficient absorption of other cannabis terpenes, making it a critical component in the overall effect unique to each strain.  Whether you’re looking to uplift your mood or relieve stress, knowing how much limonene is in your cannabis can play a key role in selecting the ideal strain.  Feel free to ask any of our knowledgeable patient consultants to assist with any questions you may have. Some studies have suggested limonene’s anti-inflammatory nature may play a vital role in possible cancer prevention. Some studies looked at the efficacy of limonene for potentially treating asthma with promising results.  Other studies examined its anxiolytic effects, indicating limonene can aid with anxiety related conditions.

Caryophyllene - Caryophyllene is an oxygenated terpenoid, usually a metabolic by product of caryophyllene. It’s use as an antifungal is highly effective with certain species. In addition, caryophyllene oxide has also been indicated as an anticoagulant with platelets.

Terpinolene – Terpineol is a useful terpene for medical cannabis patients because it possesses several key therapeutic properties. Studies show that this terpene can help manage pain and inflammation, reduce the frequency and intensity of seizures, act as a gastroprotective, and kill bacteria.

Camphene – Terpenes were previously thought to only be responsible for cannabis' flavor. Camphene, from the minor group of terpenes in hemp, displays impressive characteristics that could make it effective in the prevention of heart disease.

 

 

 

Human Endocannabinoid System

CB1 & CB2 RECEPTORS

After 35 years of research, scientists have only just begun to understand the importance of the Human Endocannabinoid System (HEcS). The discovery of the HEcS is arguably the most important discovery in human physiology in the late Twentieth Century. Research has revealed that the HEcS is responsible for maintaining and controlling the body’s homeostasis, or balanced regulation of every system in the body. It does that through two known receptors called CB1 & CB2.

While the body produces its own endogenous cannabinoids, many scientists suggest that most people are now suffering from “Cannabinoid Deficiency”. Without enough cannabinoids in our diet, the HEcS operates at less than peak efficiency, resulting in a general decline in overall health. Supplementing our diets with full spectrum phytocannabinoids may be an essential component to achieving optimal health.

The Endocannabinoid System is found in every animal, except for insects, and regulates a broad range of biological functions. The ECS is a biochemical control system of neuromodulatory lipids (molecules that include fats, waxes, sterols and fat-soluble vitamins such as vitamins A, D, E and K and others) and specialized receptors configured to accept certain cannabinoids. In general, a given receptor will accept only particular classes of compounds and will be unaffected by other compounds, just as a specific key is needed to open a lock.

Specialized receptors are located throughout the human body, including but not limited to, in the hippocampus (memory, learning), the cerebral cortex (decision-making, emotional behavior), the cerebellum (motor control, coordination), putamen (movement, learning), the hypothalamus (appetite, body temperature) and the mygdala (emotions). When a specific cannabinoid or combination of cannabinoids bind to a specialized receptor, an event or a series of events, is triggered in the cell, resulting in a change in the cell’s activity, its gene regulation and/or the signals that it sends to neighboring cells. This process is called “signal transduction.”

First detected in the brain, science now shows that CB1-R are also located in many other organs, connective tissues, gonads and glands. CB1-R are not found in the medulla oblongata (the part of the brain stem, responsible for respiratory and cardiovascular functions). CB1-R play an important role in the coordination of movements, spatial orientation, sensory perceptions (taste, touch, smell, hearing), cognitive performance and motivation.

The most important function of the CB1-R is the reduction of excessive or inadequate signaling by the neurotransmitters (messengers) in the brain. By the activation of the CB1-R, the hyperactivity or hypoactivity of the messengers (e.g., serotonin, dopamine) is regulated back into balance. For example, when THC binds to CB1-R, activity in the pain circuits is inhibited, thus resulting in reduced pain. Many other symptoms such as nausea, muscle spasticity and seizures can be alleviated or diminished with cannabinoid therapy.

CB2-R are primarily associated with the immune system and found outside of the brain in such places as the gut, spleen, liver, heart, kidneys, bones, blood vessels, lymph cells, endocrine glands and reproductive organs. For example, CBD is keyed to CB2-R, and good evidence shows CBD is a beneficial therapeutic strategy to lessen the impact of inflammatory and neuro-inflammatory diseases. Until recently, it was believed that CB-2R played no role with nerve cells or bundles. However, studies now show that it also plays an important role in the signal processing of the brain.

A third receptor that gets little attention is the transient receptor potential vanilloid-type one (TRPV1). The function of TRPV1 is to detect and regulate body temperature. In addition, TRPV1 is responsible for the sensations of extreme external heat and pain and is subject to desensitization. Therefore, if continuously stimulated, the pathway will eventually slow down or even stop. This raises therapeutic possibilities for agents to effectively treat certain kinds of neuropathic pain.

 

Content Source: MedicalJane.com. This information is included for educational purposes only. We in no way assert any medical advice. Please do your own research and consult with your physician before use of any product.